Behandlung von Psoriasis nona C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women — NEJM Behandlung von Psoriasis nona

Background Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed.

N Engl J Med ; Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events.

Full Text of Background We conducted a Behandlung von Psoriasis nona, nested case—control study among 28, apparently healthy postmenopausal women over a mean follow-up period of three years to assess the risk of cardiovascular events associated with base-line levels of markers of inflammation. The markers included high-sensitivity C-reactive protein hs-CRPserum amyloid A, interleukin-6, and soluble intercellular adhesion molecule type 1 slCAM We also studied homocysteine and several lipid and lipoprotein measurements.

Cardiovascular events were defined as death from coronary heart disease, nonfatal myocardial infarction or stroke, or the need for coronary-revascularization procedures. Full Text of Methods Of the 12 markers measured, hs-CRP was the strongest univariate predictor of the risk of cardiovascular events; the relative risk of events for women in the highest as compared with the lowest quartile for this marker was 4.

Other markers significantly associated with the risk of cardiovascular events were serum amyloid A relative risk for the highest as compared with the lowest quartile, 3.

Behandlung von Psoriasis nona levels of hs-CRP and serum amyloid A were significant predictors of risk even in the subgroup of women with LDL cholesterol levels below mg per deciliter 3. In multivariate analyses, the only plasma markers that independently predicted risk were hs-CRP relative risk for the highest as compared with the lowest quartile, 1. Full Text of Results The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying women at risk for cardiovascular events.

Full Text of Discussion Half of all myocardial infarctions occur in persons Behandlung von Psoriasis nona whom plasma lipid levels are normal. However, the clinical value of many of these markers has been limited because of inadequate standardization of assay conditions, inconsistency of prospective data, or lack of evidence of significant improvement in the prediction of risk over that afforded by standard lipid screening alone.

With the recognition that atherosclerosis is an inflammatory process, 3 several plasma markers of inflammation have also been evaluated as potential tools for prediction of the risk of coronary events.

Among them are markers of systemic inflammation produced in the liver, such as high-sensitivity C-reactive Behandlung von Psoriasis nona hs-CRP and serum amyloid A; cytokines such as interleukin-6; and adhesion molecules such as soluble intercellular adhesion molecule type 1 sICAM For example, a widely held clinical view is that levels of markers of inflammation vary too greatly over time to allow accurate prediction of risk.

Behandlung von Psoriasis nona, few prospective studies have measured all these markers of inflammation in a single group of patients, so the relative usefulness of each marker cannot be easily evaluated. In addition, data supporting the hypothesis that markers of inflammation significantly increase the predictive value of lipid screening are scant and are limited almost exclusively to data from studies of hs-CRP in middle-aged men.

In addition, to allow comparison with other proposed markers, we measured plasma levels of Lp a lipoprotein Behandlung von Psoriasis nona homocysteine. We thus were able to evaluate directly the relative value of each of these 12 measurements as an independent predictor of future cardiovascular events in a large cohort of apparently healthy women. We also sought to determine whether the measurement of markers of inflammation in addition to standard screening of lipid levels might provide a clinically useful method for improving overall prediction of the risk of cardiovascular events.

For this analysis, case subjects were study participants from whom a base-line blood sample was obtained who subsequently had a cardiovascular event defined as death from coronary heart disease, nonfatal myocardial infarction or stroke, or a coronary-revascularization procedure during a mean follow-up period of three years.

Myocardial infarction was classified as confirmed if symptoms met the criteria of the World Health Organization 15 and if the event was associated with abnormal levels of cardiac enzymes or diagnostic electrocardiographic changes.

Stroke was classified as confirmed if the patient had a new neurologic deficit that lasted more than 24 hours. Computed tomographic scans or magnetic resonance images were available for the majority of women in whom stroke occurred. Performance of revascularization procedures was confirmed by review of hospital records. Death from coronary heart disease was confirmed by review of the autopsy report, the death certificate, medical records, or information from family members regarding the circumstances of death.

For each woman who had a confirmed cardiovascular event during follow-up, two control subjects of the same age within one year and smoking status former smoker, current smoker, or nonsmoker were selected from among the remaining study participants from whom a base-line blood sample had click here obtained and who remained free of reported cardiovascular disease during follow-up.

With use of these criteria, case subjects and control subjects were selected. Base-line plasma samples from each woman with an event and each control subject were thawed and assayed for hs-CRP, serum amyloid A, and Lp a lipoprotein with use of latex-enhanced immunonephelometric assays on a BN II analyzer Dade Behring, Newark, Del. Apolipoprotein A-I and apolipoprotein B were simultaneously measured with this device by immunoassay.

Total cholesterol, HDL cholesterol, and directly obtained LDL cholesterol more info were measured on a Hitachi analyzer Roche Diagnostics, Indianapolis with reagents from Roche Diagnostics and Genzyme Cambridge, Mass. Samples were analyzed in triplicate and in random order so as to reduce systematic bias and interassay variation.

Means and proportions for risk factors for cardiovascular events at base line were calculated for women who had cardiovascular events during follow-up and those who did not. Analysis of trends was used to test for associations between increasing levels of each plasma variable and the risk of future cardiovascular events, after the sample was divided into quartiles according to the distribution of control values for that marker.

We evaluated the combined role of lipid levels and markers of inflammation as predictors of the risk of Behandlung von Psoriasis nona cardiovascular events in a series of analyses in which we explored the sensitivity and robustness of our findings from a clinical perspective. First, we used the likelihood-ratio test to determine whether logistic-regression models that included measurements of lipid variables and markers of inflammation provided a significantly better fit than did logistic-regression models limited to lipid measurements alone.

Second, to estimate the clinical relevance of these effects, we computed the area under receiver-operating-characteristic curves for prediction models based on lipid measurements alone and for models based on measurements of both lipid levels and markers of inflammation.

Third, Behandlung von Psoriasis nona divided the study participants into nine groups according to low, medium, and high levels of total cholesterol and low, medium, and high levels of each marker of inflammation. In these analyses, logistic regression was used to evaluate simultaneously the risk of future cardiovascular events in each of the nine groups; the group of women in the lowest third for total cholesterol and in the lowest third for the respective marker of inflammation was considered the reference group.

Finally, to address the clinical need for improved assessment of risk among persons with cholesterol levels currently considered safe, we performed a subgroup analysis of study participants with LDL cholesterol levels of less learn more here mg per deciliter 3. All P values were two-tailed, and values of less than 0. All confidence intervals were calculated at the 95 percent level.

The base-line characteristics Behandlung von Psoriasis nona the women who subsequently had cardiovascular Behandlung von Psoriasis nona case subjects and those who remained free of reported cardiovascular disease controls are shown in Table 1 Table 1 Base-Line Clinical Characteristics of the Study Participants. As expected, women who had cardiovascular events were heavier at base line than those who remained free of cardiovascular disease and were more likely to have hypertension, diabetes, or a parental history of premature myocardial infarction before the age of 60 years.

The frequency of exercise, the frequency of alcohol consumption, and rate of use of hormone-replacement therapy were similar in the two groups. Because of matching, the women who had cardiovascular events and the control subjects were virtually identical with respect to mean age and smoking status.

Base-line levels of Lp a lipoprotein were somewhat Psoriasis Anfangsstadium and levels of apolipoprotein A-I somewhat lower among the women with events than among control subjects, but these differences were not significant.

Table 3 Table 3 Relative Risk of Cardiovascular Events According to Base-Line Plasma Levels of Markers of Inflammation and Lipids. Measurements of hs-CRP, serum Behandlung von Psoriasis nona A, sICAM-1, and interleukin-6 were predictive of the risk of future cardiovascular events. Of the 12 measures, the level of hs-CRP was the most powerful predictor of risk in the univariate analysis relative risk for women in the highest quartile as compared with the lowest quartile, 4.

Of the lipid variables, the ratio of total cholesterol to HDL cholesterol relative risk, 3. Nonsignificant von Psoriasis Volksmittel befreien were observed for apolipoprotein A-I and Lp a lipoprotein.

As reported previously, 16 increasing levels of homocysteine were also associated with increased risk. Levels of several markers of inflammation were highly correlated. For example, the Behandlung von Psoriasis nona coefficient for the relation between hs-CRP and Behandlung von Psoriasis nona amyloid A was 0.

In contrast, correlations between markers of inflammation and lipid measures were low; less than 10 percent of the variance in any marker of inflammation was explained by any of the lipid measures. To determine the independent predictive value of each of the 12 measures, we performed a series of logistic-regression analyses that simultaneously controlled for increasing quartiles of hs-CRP, Behandlung von Psoriasis nona amyloid A, sICAM-1, interleukin-6, homocysteine, and Lp a lipoprotein and the ratio Behandlung von Psoriasis nona total cholesterol to HDL cholesterol because of colinearity with this ratio, levels of apolipoprotein A-I, apolipoprotein B, die Behandlung von Psoriasis LDL cholesterol were not included in these analyses.

As shown in Table 4 Table 4 Adjusted Relative Risk of Cardiovascular Events Associated with an Increase of One Quartile in the Concentration of Each Plasma Marker. In similar models that were limited to markers of inflammation, hs-CRP remained an independent predictor of the risk of future cardiovascular events. In contrast, the beta coefficients associated with serum amyloid A, sICAM-1, and interleukin-6 decreased substantially and were no longer statistically significant in analyses that included control for the quartile of hs-CRP.

To explore whether any of the markers of inflammation added to the predictive value Behandlung von Psoriasis nona lipid-based screening, several additional analyses were performed. First, we computed the relative risk of cardiovascular events in analyses in which study participants were stratified into nine groups according to total cholesterol level as well as each marker of inflammation. As shown Behandlung von Psoriasis nona Figure 1 Figure 1 Relative Risk of Cardiovascular Events among Apparently Healthy Postmenopausal Women According to Base-Line Levels of Total Cholesterol and Markers of Inflammation.

Each marker of inflammation improved risk-prediction models based on lipid testing alone, an effect that was strongest for hs-CRP and serum amyloid A. In contrast, the risk tended to be highest among women with high total cholesterol levels and high levels of a marker of inflammation.

However, even among the women with low total cholesterol levels, the risk of cardiovascular events was significantly higher among those with high levels of hs-CRP and serum amyloid A than among those Behandlung von Psoriasis nona low levels of these markers Figure 1.

These associations were also evident, but to a lesser extent, for interleukin-6 and sICAM In all of the analyses, these additive effects were robust with respect to the choice of cutoff point and the choice of the lipid variable analyzed. For example, the addition of hs-CRP to lipid screening produced a significant and additive predictive effect when regression analyses were based on the Psoriasis an den Fingern haben Nägel Foto me points for quartiles rather than cutoff points for the division of the study group into thirds and on analysis of the Salbe bei der von of total cholesterol to HDL cholesterol rather than on total cholesterol alone.

Second, Behandlung von Psoriasis nona tests Behandlung von Psoriasis nona used to compare the fit Behandlung von Psoriasis nona predictive models that were based on measurement of a marker of inflammation in over Vitamine B6 und B12 bei Psoriasis September with lipids to the fit of models based on lipid measurements alone. In these analyses, each of the markers of inflammation significantly improved the usefulness of lipid screening in predicting risk.

Third, as a measure of clinical usefulness, we computed the area under the receiver-operating-characteristic curve associated with risk-prediction models based on lipid screening alone and compared it with those based on a combination of lipids and markers of inflammation. In these analyses, Behandlung von Psoriasis nona use of hs-CRP levels in addition to total cholesterol increased the area under the receiver-operating-characteristic curve from 0.

Similar effects were observed for analyses that included serum amyloid A, sICAM-1, and interleukin Use of the serum amyloid A level in addition to the ratio of total cholesterol to HDL cholesterol increased the area under the curve from 0. This effect was strongest for hs-CRP and serum amyloid A.

In this subgroup, the relative risks of cardiovascular events for women in the lowest to the highest quartiles of hs-CRP were 1. After adjustment for body-mass index, the presence or absence of hypertension, diabetes, or a parental history of premature myocardial infarction, and the level of HDL cholesterol, the increased risk for women in the highest quartile of hs-CRP at base line remained statistically significant relative risk, 3.

The mean LDL cholesterol level in this subgroup analysis was mg per deciliter 2. In this prospective study of apparently healthy postmenopausal women, four markers of inflammation — hs-CRP, serum amyloid A, interleukin-6, and sICAM-1 — were found to be Behandlung von Psoriasis nona predictors of the risk of future cardiovascular events.

In addition, measurement of these markers increased the predictive value of models based only on standard lipid screening. Of the 12 plasma measures evaluated in this study, hs-CRP was the most significant predictor of the risk of cardiovascular events; when measured with a widely available, standardized commercial assay, 18 this marker distinguished between women at high risk and those at low risk, even in the subgroup of women with LDL cholesterol levels below mg per deciliter mean, mg per deciliterBehandlung von Psoriasis nona target considered safe in the current guidelines of the National Cholesterol Education Program.

The results of the current study have several important implications. First, the findings confirm that in women, markers of inflammation are important predictors of the risk of cardiovascular events. Previous Behandlung von Psoriasis nona on this issue have been derived largely from studies of middle-aged men.

Second, because Behandlung von Psoriasis nona used a commercially available assay to measure plasma hs-CRP, 18 our results provide clinically relevant confirmation of previous findings in this cohort, which were obtained with use of an experimental assay. Third, we believe the current results have public health implications both in terms of the prediction of the risk of cardiovascular events Behandlung von Psoriasis nona in terms of the use of inhibitors of 3-hydroxymethylglutaryl coenzyme A Visit web page reductase for primary prevention.

Although the results of large-scale randomized trials have indicated that HMG-CoA reductase inhibition is effective even among persons at einige Pillen helfen bei Psoriasis risk as defined by standard Behandlung von Psoriasis nona screening, 19,20 the large Behandlung von Psoriasis nona of patients who would need to be treated and the high Behandlung von Psoriasis nona of this approach have limited the clinical application of those findings.

Thus, our observation that measurement of markers of inflammation such as hs-CRP can significantly improve models for the prediction of cardiovascular risk may lead to better clinical identification of patients who might benefit from primary prevention and for whom the cost-to-benefit ratio for long-term Behandlung von Psoriasis nona of statins would be improved.

This issue is particularly intriguing because recent data from the Cholesterol and Recurrent Events trial indicate that long-term therapy with pravastatin significantly lowers plasma levels of hs-CRP 21 and that the efficacy of pravastatin in lowering the rate of cardiovascular events Behandlung von Psoriasis nona greatest in those with increased levels of hs-CRP.

Several limitations of these analyses merit consideration. First, our cohort comprised apparently healthy postmenopausal women, and thus the results may not apply to younger women, who may also be at increased risk for cardiovascular events.

Second, we check this out each marker of inflammation at study entry and thus could not evaluate the effects of changes in the levels of these markers over time. However, follow-up studies have found that levels of hs-CRP are stable over long periods, as long as measurements are not made within two to three weeks of an acute infection.

Finally, although base-line levels of several markers of inflammation were greater than normal among women at risk for future cardiovascular events, the mechanisms underlying these elevations remain uncertain. In this study, we did not find significant associations between cardiovascular risk and titers of IgG antibodies against Chlamydia pneumoniae, Helicobacter pylori, herpes simplex virus, or cytomegalovirus or between titers of these antibodies and plasma levels of hs-CRP.

Thus, it is also possible that the inflammation that we detected in apparently healthy women who were at risk for future cardiovascular Behandlung von Psoriasis nona may be an indirect marker of an enhanced cytokine response to a variety of inflammatory stim-uli that ultimately prove critical Behandlung von Psoriasis nona the time of acute plaque rupture.

In conclusion, in this prospective evaluation of 12 plasma variables, hs-CRP proved to be the strongest and most significant predictor of the risk of future cardiovascular events.

As in previous population-based epidemiologic studies, half of all cardiovascular events in our cohort occurred among women without overt hyperlipidemia. Thus, these data raise the possibility that the addition of hs-CRP to standard lipid screening will generate an improved method for identifying persons at high risk for future cardiovascular events, who would thus be candidates for primary-prevention interventions such as the use of HMG-CoA reductase inhibitors.

Supported by grants HL and HL from the National Heart, Lung, and Blood Institute, by a grant CA from the National Cancer Institute, and by an Established Investigator Award from the American Heart Association to Dr.

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Free Radical Research Nature Reviews Cardiology Edmonds, Averria Sirkin Martin, Barton W. Thurston, Julia Paulson, Peter J. The Journal of Clinical Hypertension Gerard Pasterkamp, Hester M. Current Opinion in Lipidology Clinical Physiology and Functional Imaging. Cem Gabay, Iain B McInnes, Arthur Kavanaugh, Katie Tuckwell, Micki Klearman, Jennifer Pulley, Naveed Sattar. Annals of the Rheumatic Diseases Birks, Venkatesh Mani, Luca Biasiolli, Matthew D.

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Korean Genome and Epidemiology Study. Gholamreza Houshmand, Mohammad Taghi Mansouri, Bahareh Naghizadeh, Ali Asghar Hemmati, Mahmoud Hashemitabar. International Immunopharmacology 38 Yao Jiang, Jingjing Zhang, Yanggang Yuan, Xiaoming Zha, Changying Xing, Chong Shen, Zhixiang Shen, Chao Qin, Ming Zeng, Guang Yang, Huijuan Mao, Bo Zhang, Xiangbao Yu, Bin Sun, Read more Ouyang, Xueqiang Xu, Yifei Ge, Jing Wang, Lina Zhang, Chen Cheng, Caixia Yin, Behandlung von Psoriasis nona Zhang, Huimin Chen, Haoyang Ma, Ningning Wang.

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International Journal of Hematology K S Stote, R P Tracy, P R Taylor, D J Baer. European Journal of Clinical Nutrition 70 Albert, Nelsy Castro-Webb, Patricia F. Coogan, Paul Ridker, Harvey W. Journal of Urban Health 93 Zhi-Quan Wang, Man-Tian Chen, Rui Zhang, Yi Zhang, Wei Li, Yi-Gang Li. Journal of Cardiovascular Pharmacology 67 Semmens, Charles Dumke, John C. Journal of Occupational and Environmental Medicine Suzanne C van Dijk, Anke W Enneman, Karin MA Swart, Janneke P van Wijngaarden, Annelies C Ham, R de Jonge, Henk J Blom, Edith J Feskens, Johanna Marianne Geleijnse, Natasja M van Schoor, Rosalie Behandlung von Psoriasis nona Dhonukshe-Rutten, Renate T de Jongh, Paul Lips, Lisette CPGM de Groot, Andre G Uitterlinden, Ton H van den Meiracker, Francesco US Mattace-Raso, Nathalie van der Velde, Yvo M Smulders.

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Biochemical Background and Clinical Significance. Metabolic Syndrome and Behandlung von Psoriasis nona Disorders 14 Clinical Rheumatology 35 Hon-Yen Wu, Yu-Sen Peng, Hung-Yuan Chen, Wan-Chuan Tsai, Behandlung von Psoriasis nona Yang, Shih-Ping Hsu, Mei-Fen Pai, Hui-Min Lu, Ju-Fen Chiang, Mei-Ju Ko, Su-Ying Wen, Hsien-Ching Chiu.

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Testing Pharmacological Profiles with Biomarkers Relevant to Cardiovascular Profiles. Biomarkers in Cardiovascular Disease, Panagiota Pietri, Charalambos Vlachopoulos. Postmenopausal Hypertension and Coronary Artery Disease Risk. Hypertension and Cardiovascular Disease, Ilonka Rohm, Daniel Behandlung von Psoriasis nona, Rudin Pistulli, Marcus Franz, P. Christian Schulze, Christian Stumpf, Atilla Yilmaz. Journal of Immunology Research Oxidative Medicine and Cellular Longevity Ya-ting Wang, Dan-yan Xu.

Hamilton, Yuheng Cai, Rupinder Kaur, Grant W. Lipid-Coated Gold Nanoparticles as Probes for Membrane Binding. Chemical and Synthetic Approaches in Membrane Biology, Shokoufeh Hajsadeghi, Mandana Chitsazan, Mitra Chitsazan, Behandlung von Psoriasis nona Salehi, Ahmad Amin, Majid Maleki, Nima Babaali, Seifollah Abdi, Maryam Mohsenian. Research in Cardiovascular Medicine 5. Chang Yeop Han, Chongren Tang, Myriam E. Guevara, Hao Wei, Tomasz Wietecha, Baohai Shao, Savitha Subramanian, Mohamed Omer, Shari Wang, Kevin D.

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Thompson, Malcolm West, Harvey D. The LIPID biomarker study. European Journal of Clinical Investigation 45 Bin Lu, Ming Zhao, Weimin Jiang, Jian Ma, Cuihua Behandlung von Psoriasis nona, Jiaqing Shao, Ping Gu. Yook Chin Chia, Hooi Min Lim, Siew Mooi Ching, Tatsuo Shimosawa. Christopher Blesso, Catherine Andersen, Maria Fernandez. Eggs Effects on HDL-C Metabolism, Inflammation, and Insulin Resistance.

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Associated Roles of the Metabolic Syndrome, Inflammation, and Insulin Resistance. Montserrat Heilige Quelle der Psoriasis, Fernando de la Cuesta, Gloria Alvarez-Llamas, Laura Gonzalez-Calero, Gema Ruiz-Hurtado, Rafael Moreno-Luna, Laura Mourino-Alvarez, Tamara Sastre-Oliva, Julian Segura, Luis R.

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Renal Failure 37 Archives of Physiology and Biochemistry Stephen Zewinger, Christiane Drechsler, Marcus E. Kleber, Alexander Dressel, Julia Riffel, Sarah Triem, Marlene Lehmann, Chantal Kopecky, Marcus D.

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Central role of the gut microbiota. Sheu, Katarina Krajina, Stephen B. Brain, Behavior, and Immunity 48 Seung Hwan Moon, Young Seok Cho, Tae Soo Noh, Joon Young Choi, Byung-Tae Kim, Kyung-Han Lee.

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Royal, Anthony Lucci, Christopher W. Bassett, Li-E Wang, Qingyi Wei, Christopher I. Journal of Clinical Oncology Gene Chirinos, Josefina Medina-Lezama, Belissa Salinas-Najarro, William Arguelles, Maria M. Llabre, Neil Schneiderman, Roberto Paz-Manrique, Juan F. Bolanos, Zubair Khan, Julio A. Journal of Behavioral Medicine 38 Krithika Selvarajan, Chandrakala Aluganti Narasimhulu, Reena Bapputty, Sampath Parthasarathy. Potential Use in Atherosclerosis. Journal of Medicinal Food 18 Michael Hendryx, Jennifer Entwhistle.

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Pringle, Kym Rae, Loretta Weatherall, Sharron Hall, Christine Burns, Roger Behandlung von Psoriasis nona, Eugenie R. Frontiers in Immunology 6. Adriana Cuervo, Clara G. Journal of the American College of Nutrition 34 Yangbo Sun, Chao Qiang Jiang, Kar Keung Cheng, Wei Sen Zhang, Gabriel M. Leung, Tai Hing Lam, C.

The Guangzhou Biobank Cohort Study. Annals of Human Biology 42 Serenella Savini, Harleah G. Buck, Victoria Vaughan Dickson, Silvio Simeone, Gianluca Pucciarelli, Roberta Fida, Maria Matarese, Rosaria Alvaro, Ercole Vellone. Journal of Advanced Nursing Sabina Halappanavar, Ungarische Regelung der Behandlung von Psoriasis Thoustrup Saber, Nathalie Decan, Keld Alstrup Jensen, Dongmei Wu, Nicklas Raun Jacobsen, Charles Guo, Jacob Rogowski, Ismo Behandlung von Psoriasis nona. Koponen, Marcus Levin, Anne Mette Madsen, Rambabu Atluri, Valentinas Snitka, Renie K.

Environmental and Molecular Mutagenesis Ritsuko Nishide, Michiko Ando, Hidemitsu Funabashi, Yoshiko Yoda, Masataka Nakano, Masayuki Shima. Environmental Health and Preventive Medicine 20 H-Y Su, H-C Lee, W-Y Read article, S-Y Huang. European Journal of Clinical Nutrition 69 Kenshiro Arao, Takayuki Fujiwara, Yousuke Taniguchi, Hiroyuki Jinnouchi, Harue Sasai, Mitsunari Matsumoto, Hiroshi Funayama, Junya Ako, Shin-ichi Momomura.

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Role of lipoproteins and metabolic and inflammatory markers. Toxicology and Applied Pharmacology Irfan Zeb, Matthew Budoff. Does it Perform Better than Other Cardiovascular Risk Stratification Tools?.

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Molecular and Cellular Behandlung von Psoriasis nona. Human Molecular Genetics Athanasios Koutsos, Julie A. An Apple a Day Keeps the Doctor Away — Inter-Relationship Between Apple Consumption, the Gut Microbiota and Cardiometabolic Disease Risk Reduction. Diet-Microbe Interactions in the Gut, Nix, Rudolf Zirwes, Volkhard Bangert, Raimund Peter Kaiser, Matthias Schilling, Ulrike Hostalek, Rima Obeid.

The Journal of Cardiovascular Nursing 30 Neurocognitive and Physiological Mechanisms Linking Stress and Health. Strength and Conditioning Journal Thrombosis and Haemostasis Suzanne Fredericks, Sepali Guruge. Advances in Nursing Science 38EE Sung-Ho Shin, Jia-Le Song, Myoung-Gyu Park, Mi-Hyun Park, Sung-Joo Hwang, Kun-Young Park. Nutrition Research and Practice 9 Evolution, Medicine, and Public Health Xiaoming Please click for source, Wei Mao, Yueyang Chai, Jin Dai, Qian Chen, Lihui Wang, Qin Zhuang, Behandlung von Psoriasis nona Pan, Minli Chen, Guibao Ni, Zhaoquan Huang.

Journal of Atherosclerosis and Thrombosis 22 Divani, Xianghua Luo, Yvonne H. Nicole Noren Hooten, Ngozi Ejiogu, Alan B. International Journal of Evolutionary Biology Sami Aldaham, Janet A. Sherry Chow, Iman A. Behandlung von Psoriasis nona Journal of Inflammation Dinka Pavicic Baldani, Lana Skrgatic, Roya Ougouag. Important Underrecognised Cardiometabolic Risk Factor in Reproductive-Age Women.

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Lloyd-Jones, Jeremiah Stamler, Amber Pirzada, Sanjiv J. Preventive Medicine Reports 2 Frontiers in Cardiovascular Medicine 1. Christopher Joseph Carrubba, Michael J. Blaha, Khurram Nasir, Andrew Paul DeFilippis. Current Cardiovascular Risk Reports 8.

Behandlung von Psoriasis nona Li, Chunsheng Qu, Pingshuan Dong. Coronary Artery Disease 25 Seyed Mehdi Hoseini, Ali Kalantari, Mohsen Afarideh, Sina Noshad, Aram Behdadnia, Manouchehr Nakhjavani, Alireza Esteghamati. Mei-Ju Ko, Yu-Sen Peng, Hung-Yuan Chen, Shih-Ping Hsu, Mei-Fen Pai, Ju-Yeh Yang, Su-Ying Wen, Shiou-Hwa Jee, Hon-Yen Wu, Behandlung von Psoriasis nona Chiu.

Journal of the American Academy of Dermatology 71 Swapna Upadhyay, Tobias Stoeger, Leema George, Mette C Schladweiler, Urmila Kodavanti, Koustav Ganguly, Holger Schulz. Particle and Fibre Toxicology Behandlung von Psoriasis nona Chandra, Manish Bansal, Tiny Nair, S. Iyengar, Rajeev Gupta, Subhash C.

Sawhney, Nakul Sinha, A. Pancholia, Sundeep Mishra, Ravi R. Kasliwal, Saumitra Kumar, Unni Krishnan, Sanjay Kalra, Anoop Misra, Usha Shrivastava, Seema Gulati. Indian Heart Journal 66S1-S Ryan Koenig, Jonathan R Dickman, Chounghun Kang, Tianou Zhang, Behandlung von Psoriasis nona Chu, Behandlung von Psoriasis nona Li Ji.

Alan Yeung, Hosen Kiat, A Robert Denniss, Birinder S Cheema, Alan Bensoussan, Bianca Machliss, Ben Colagiuri, Dennis Chang.

Lack of association with CRP levels in patients with coronary artery disease. Journal of the Renin-Angiotensin-Aldosterone Behandlung von Psoriasis nona Hongyan Li, Casimir Akoh, Jing Li, Huan Rao, Zeyuan Behandlung von Psoriasis nona. Food Safety Chemistry, Thimoteus Speer, Frederick O.

Holy, Stephen Zewinger, Felix L. Heine, Vera Jankowski, Joachim Jankowski, Giovanni G. Camici, Alexander Akhmedov, Danilo Fliser, Thomas Behandlung von Psoriasis nona. European Heart Journal 35 Wiener klinische Wochenschrift Kyjovska, Sabina Halappanavar, Carole L.

Nanomedicine and Nanobiotechnology 6: Ming Shan, Xudong Yang, Majid Ezzati, Nishi Chaturvedi, Emma Coady, Alun Hughes, Yuhui Shi, Ming Yang, Yuanxun Zhang, Jill Baumgartner. Environmental Research Mohd Ashraf Ganie, Saqib Hassan, Sobia Nisar, Nasir Shamas, Aafia Rashid, Ishfaq Ahmed, Syed Douhat, Syed Mudassar, Vicar M.

Gynecological Endocrinology 30 Ming Hui Chen, Lauren H. Blackington, Jing Zhou, Tammy F. Chu, Kimberlee Gauvreau, Karen J. Frontiers in Physiology 5. Md Quamrul Hassan, Md Bei Psoriasis Akhtar, Mohd. Akhtar, Shahid Hussian Ansari, Javed Behandlung von Psoriasis nona, Syed Ehtaishamul Haque, Abul Kalam Najmi. Toxicology Mechanisms and Methods Megumi Kato, Tomoya Kinumi, Mariko Yoshioka, Mari Goto, Shin-ichiro Fujii, Akiko Takatsu.

Analytical and Bioanalytical Chemistry. Nutrition, Metabolism and Cardiovascular Diseases 24 Susan Sam, Theodore Mazzone. Translational Research Behandlung von Psoriasis nona, Condition juckende Haut und Schläfrigkeit Wurzel of Gerontology and Geriatrics. Prostaglandins, Leukotrienes and Essential Fatty Acids PLEFA 91 Sairam Parthasarathy, Monica M.

Vasquez, Marilyn Halonen, Richard Bootzin, Stuart F. The American Journal of Medicine. Subroto Acharjee, Jin-Rong Zhou, Tarec K. Jared R Mayers, Chen Wu, Clary B Clish, Peter Kraft, Margaret E Torrence, Brian P Fiske, Chen Yuan, Ying Bao, Mary K Townsend, Shelley S Tworoger, Shawn M Davidson, Behandlung von Psoriasis nona Papagiannakopoulos, Annan Yang, Talya L Dayton, Shuji Ogino, Meir J Stampfer, Edward L Giovannucci, Zhi Rong Qian, Douglas A Rubinson, Jing Ma, Howard D Sesso, John M Gaziano, Barbara B Cochrane, Simin Liu, Jean Wactawski-Wende, JoAnn E Manson, Michael N Pollak, Alec C Kimmelman, Amanda Souza, Kerry Pierce, Thomas J Wang, Robert E Gerszten, Charles S Fuchs, Matthew G Vander Heiden, Brian M Wolpin.

Nature Medicine 20 Strachan, Frank Thies, Lorna S. Hardcastle, Alexandra Mavroeidi, William G. British Journal of Nutrition Journal of Fluorescence 24 Nursing Outlook 62 Annals of the Rheumatic Diseases 73 Prakul Chanthong, Keswadee Lapphra, Supawan Saihongthong, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Wanatpreeya Phongsamart, Supattra Rungmaitree, Nantaka Kongstan, Kulkanya Chokephaibulkit.

Ravi Jahagirdar, Haiyan Zhang, Salman Azhar, Jennifer Tobin, Sarah Attwell, Raymond Yu, Jin Wu, Kevin G. Young, Rai Ajit K. Behandlung von Psoriasis nona Nallasamy, Hongwei Si, Pon Velayutham Anandh Babu, Dengke Pan, Yu Fu, Elizabeth A. Brooke, Halley Shah, Wei Zhen, Hong Behandlung von Psoriasis nona, Dongmin Liu, Yunbo Li, Zhenquan Jia.

The Journal of Nutritional Behandlung von Psoriasis nona 25 Aparna Pandey, Amit Kumar Shrivastava, Kiran Saxena. Correlation with Degree of Disability.

Neurochemical Research 39 Jang Hoon Lee, Dong Heon Yang, Please click for source Sik Park, Yongkeun Cho, Won Kee Lee, Byung Yeol Chun, Shung Chull Chae.

Clinical and Experimental Hypertension 36 Jui-Hsiu Tsai, Chang-Hung Kuo, Pinchen Yang, Kuang-Hung Cheng, Behandlung von Psoriasis nona Wang, Cheng-Chung Behandlung von Psoriasis nona, Chih-Hsing Hung. International Behandlung von Psoriasis nona of Molecular Sciences 15 Koshi Nakamura, Masaru Sakurai, Katsuyuki Miura, Yuko Morikawa, Shin-Ya Nagasawa, Masao Ishizaki, Teruhiko Kido, Yuchi Naruse, Motoko Nakashima, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa.

Georg Wick, Bojana Jakic, Maja Buszko, Marius C. Nature Reviews Cardiology 11 Milena Monfort-Pires, Emanuel P. Folchetti, Antonela Siqueira-Catania, Camila R. Barros, Sandra Roberta Gouvea Ferreira. Journal of the American College of Nutrition 33 Linlin Xiao, Weili Liu, Jitao Li, Yuexia Xie, Mingyuan He, Jiamei Fu, Wensen Jin, Chunlin Shao.

Radiation Research Mei Shih, Jong Cherng. Molecules 19 Akihiro Shindo, Hiroshi Tanemura, Kenichiro Yata, Kazuhide Hamada, Masunari Shibata, Yasuyuki Umeda, Fumio Asakura, Naoki Toma, Hiroshi Sakaida, Takao Fujisawa, Waro Taki, Hidekazu Tomimoto, Raffaella Bonecchi. Pentraxin 3 Can Become a Novel Marker of Plaque Vulnerability. Behandlung von Psoriasis nona, Rebecca Klemm, Richard B.

The changing assessment of black carbon. Xingxing Sun, Tingting Du, Behandlung von Psoriasis nona Huo, Lixian Xu. Acta Diabetologica 51 Nutrition, Metabolism and Cardiovascular Diseases. Anthony Lynn, Shilpa Mathew, Chris T.

Moore, Jean Russell, Emma Robinson, Vithleem Soumpasi, Margo E. A Randomised Controlled Trial. Plant Foods for Human Nutrition 69 Aili Wang, Tan Xu, Tian Xu, Mingzhi Zhang, Hongmei Li, Weijun Tong, Yonghong Zhang. Future risk of ischemic stroke in a prospective cohort study among inner Mongolians in China. International Journal of Cardiology Manzoor Ahmad Bhat, Bashir Ahmad Laway, Zaffar Amin Shah, Arshad Iqbal Behandlung von Psoriasis nona, Idrees Mubarik.

Rosalyn Gross, Maureen Groer, Sandra P. Health Care for Women International 35 Makoto Hoshino, Junichi Ohtawa, Kenta Akitsu. Krishnan Thulasi Raman, Velusamy Prema, Srinivasan Ashokkumar, Ganesan Thellamudhu, Mangaiah Suresh, Narasimhan Kishorekumar, Chakrapani Lakshmi Narasimhan, J.

Thanka, Charles Emmanuel Jebaraj Walter, Sankari Durairajan, Nathakattur Behandlung von Psoriasis nona Sanddhya, Periandavan Kalaiselvi. Psychological Medicine 44 Newton, Rafael Fernandez-Botran, James J. Miller, Vicki Ellison Burns. Associations with lifetime diagnostic status and psychological context. Biological Psychology 99 Muyesser Arslan, Oya Topaloglu, Mustafa Sahin, Esra Tutal, Askin Gungunes, Evrim Cakir, Ilknur Ozturk, Basak Karbek, Bekir Ucan, Zeynep Ginis, Erman Cakal, Mustafa Ozbek, Tuncay Delibasi.

Endocrine Practice 20 The American Journal of Medicinee Ishwarlal Jialal, Sridevi Devaraj, Uthra Rajamani. Amanda J Cox, Sophia M Moscovis, C Caroline Blackwell, Rodney J Scott. Proceedings of the Royal Society B: Biological Sciences Sofie Ahlin, Maja Olsson, Anna S. Tetsuro Miyazaki, Stephanie Chiuve, Frank M.

Ridker, Peter Libby, Masanori Aikawa, Nikolaos Frangogiannis. Masaaki Fujita, Yoko K. Takada, Yoshihiro Izumiya, Yoshikazu Takada, Edward F. AGE 36 Larsen, Hans Mickley, Lotte Saaby, Axel Behandlung von Psoriasis nona. Diederichsen, Jess Lambrechtsen, Lars M. Journal of Proteomics Fertility and Sterility Do we still need to check the lipid panel?.

Cardiovascular Revascularization Medicine 15 Robin Altman, Jessica Nunez de Ybarra, Amparo C. Fabio De Giorgio, Vincenzo M. Grassi, Matteo Polacco, Vincenzo L. Is the actual classification exhaustive?. International Journal of Cardiologyee A population-based study CoLaus Study. Cytokine 66 Naomi Sakurai-Komada, Hiroyasu Iso, Kazuko A.

Koike, Ai Ikeda, Mitsumasa Umesawa, Satoyo Ikehara, Manami Inoue, Shoichiro Tsugane. Hitesh Patel, Sujay Chandran, Kausik K. New Biomarkers of Cardiovascular Disease in Diabetes. Managing Cardiovascular Complications in Diabetes, Anagha Sen, Patrick Most, Karsten Peppel.

FEBS Letters Joshua Hartman, William H Frishman. Cardiology in Review1. Elena Grossini, Carla Gramaglia, Serena Farruggio, Kevin Bellofatto, Chiara Anchisi, Invention Haut Psoriasis auf Füßen genau Mary, Giovanni Vacca, Patrizia Zeppegno.

Vascular Pharmacology 60 Monika Eichholzer, Aline Richard, Holly L. Platz, Jakob Linseisen, Sabine Rohrmann. Netherlands Heart Journal 22 Martine Morrison, Roel van der Heijden, Peter Heeringa, Eric Kaijzel, Lars Verschuren, Rune Blomhoff, Teake Kooistra, Robert Kleemann.

Ryan, Shealinna Ge, Jacob B. McLellan, Joanie Larose, Ronald J. Sigal, Pierre Boulay, Glen P. European Journal of Applied Physiology. Donges, Rob Duffield, Greg C. Applied Physiology, Nutrition, and Metabolism 39 Kropman, Andrea van Meurs, Bram Fioole, Jan Albert Vos, Hjalmar C. Annals of Vascular Surgery 28 Behandlung von Psoriasis nona of Indian College of Cardiology. Joo-Wook Sung, Sung Ho Lee, Christopher D.

Byrne, Pil-Wook Chung, Yu Sam Won, Ki-Chul Sung. Archives of Medical Research 45 Neeraj Shah, Valay Parikh, Nileshkumar Patel, Nilay Patel, Apurva Badheka, Abhishek Deshmukh, Ankit Rathod, James Lafferty.

Insights from the National Health and Nutrition Examination Http:// Holger Cramer, Romy Lauche, Heidemarie Haller, Nico Steckhan, Andreas Michalsen, Gustav Dobos.

International Journal of Cardiology. Ehimare Akhabue, Jeffrey Thiboutot, Jeh-wei Cheng, Stamatios Lerakis, Timothy J. Vittorio, Georgios Christodoulidis, Kathleen M. Olivia Gilbert, James R.

Taylor, Mark Nash, Katherine Schomer, Suzanne Groah. Obesity and Metabolic Syndrome. Handbook of Obesity, Elliott, Eric Norman, Vesna Stajic, Christine Behandlung von Psoriasis nona. A 3-Month Randomized, Placebo-Controlled Trial in Healthy Early Postmenopausal Women. Ramin Alemzadeh, Jessica Kichler. Parvin Mirmiran, Zahra Bahadoran, Mahdieh Natriumthiosulfat und Psoriasis Bewertungen, Homayoun Zojaji, Fereidoun Azizi.

Hae Chang Jeong, Inna Kim, Keun Ho Park, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Behandlung von Psoriasis nona, Yun Hyeon Kim, Hyun Ju Seon, Jae Dong Moon, Youngkeun Ahn. Circulation Journal 78 Masahiro Yamazaki, Goji Hasegawa, Saori Majima, Kazuteru Mitsuhashi, Takuya Fukuda, Hiroya Iwase, Mayuko Kadono, Mai Asano, Takafumi Senmaru, Muhei Tanaka, Michiaki Fukui, Naoto Nakamura.

Behandlung von Psoriasis nona of Saturated and Polyunsaturated Fat in Obesity-Related Inflammation. Inflammation, Advancing Age and Nutrition, Jessica Monteiro, Michael Leslie, Mohammed H. Ahra Ko, Hyesook Kim, Chan-Jung Han, Ji-Myung Kim, Hye-Won Chung, Namsoo Chang. Nutrition Research and Practice Behandlung von Psoriasis nona Reference Module in Biomedical Sciences. Psychosomatic Medicine 76 Integrative Cardiovascular Chinese Medicine, Georgios Christodoulidis, Timothy J.

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A Randomized, Controlled Trial. Jamshid Vafaeimanesh, Seyyed Fakhroldin Hejazi, Vahid Damanpak, Mostafa Vahedian, Mohammadamin Sattari, Mohammadreza Seyyedmajidi. Is Helicobacter pylori a Risk Factor?. The Scientific World Journal more info, Shu Meguro, Behandlung von Psoriasis nona Tomita, Takeshi Katsuki, Kiyoe Kato, Henpiru Oh, Akira Ainai, Ryo Ito, Toshihide Kawai, Hiroshi Itoh, Hideki Hasegawa.

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Orsatti, Ana Paula Tardivo, Gilberto Uemura, Maria Terezinha S.

Weltweit Behandlung von Psoriasis nona etwa Millionen, in Deutschland ca. Oktober von der International Federation of Psoriasis Associations erstmals als Welt-Psoriasistag ausgerufen. Eine schuppende Hautkrankheit, bei der es sich wahrscheinlich um Psoriasis handelte, wurde bereits vom griechischen Arzt Hippokrates ca. Der Ausdruck Psoriasis wurde zum ersten Mal vom Arzt Galenus verwendet, der damit eine Schuppenbildung im Augen - und Hodensackbereich umschrieb. Bei dieser handelte es sich jedoch dem heutigen Forschungsstand nach vermutlich um Ekzeme.

Allgemein werden vor allem Hautpartien befallen, die oft gedehnt werden wie die genannten Gelenke, aber auch z. Dabei nimmt die Kopfhaut-Psoriasis eine Sonderstellung ein. Die Oberhaut Epidermis eines gesunden Menschen erneuert sich innerhalb von 26 bis 27 Tagen. Bei der gesunden Haut dienen die Keratinozyten dem mechanischen, mikrobiellen und chemischen Schutz der Haut. Sie geht meist mit Nagelpsoriasis oder Gelenkbeschwerden Psoriasisartrithis einher. Der learn more here Verlauf kennzeichnet sich durch einen akuten Fieberschub.

Innerhalb von 24 Stunden steigt die Zahl der Leukozyten, der Calciumgehalt sinkt, ebenso der Behandlung von Psoriasis nona an Albumin im Blutplasma. Die Behandlung von Psoriasis nona befindet sich an den Akren das sind: Ein Vergleich zwischen Schuppenflechte-Patienten und in Alter und Geschlecht vergleichbaren Gesunden ergab, dass Psoriasis-Patienten eine vermehrte Knochenproliferation bei gleichzeitigem nicht unterschiedlichen Erosionsumfang aufweisen.

Bis heute ist allerdings nicht bekannt, ob die Psoriasis dominant oder rezessiv vererbt wird. In den betroffenen Geweben entsteht ein proinflammatorisches Milieu. Bei Psoriasis wird vermehrt das Protein Psoriasin gebildet. Hinzu kommt, dass wie bei allen Erkrankungen mit phasenhaftem Verlauf und spontanen Besserungen die Wirksamkeit von Behandlungsverfahren hinsichtlich dieser Linderung schwer einerseits Psoriasis und Impfung Placebo-Effekt und andererseits von spontaner Besserung Remission unterschieden werden kann.

Insgesamt ist Akzeptanz ein wichtiger Faktor im Umgang mit der Psoriasis. Eine Badetherapie mit schwefelhaltigem Natur- Fango und Vulkanwasser, wie sie in gewichtszunahme Elokim Salbe für Psoriasis Bewertungen van argentinischen Anden im Thermalbad Copahue angeboten wird, kann Diabetes mellitus der Haut Juckreiz, jedoch keine Heilung bewirken.

Diese Methode soll die Bedingungen am Toten Meer simulieren. Die Fische Kangalfische entfernen dabei die Hautschuppen der betroffenen Patienten. Der Excimer-Laser stellt eine der neuesten Entwicklungen in der Lasertherapie read more. Es handelt sich dabei um einen Xenon-Chlorid-Gas-Laser.

Der Laser arbeitet im UV-Schmalband-Spektrum. Zum Einsatz kommt er vor allen bei der Psoriasis und der Vitiligo. Je nach Empfindlichkeit des erkrankten Haut-Areals kann die therapeutisch notwendige Dosis gezielt angepasst werden.

Die Wirkstoffe sind Psoralene z. Diese Therapie wird oft kombiniert Behandlung von Psoriasis nona topischen Behandlungen, zur weiteren Steigerung der Wirksamkeit.

Eine Kombination von UVA und UVB. Leuchtdioden Behandlung von Psoriasis nona sind sichere, energieeffiziente und langlebige Lichtquellen. Die Elektrotherapie mit schwach dosiertem Interferenzstrom zur Behandlung wurde am Forschungszentrum Karlsruhe weiterentwickelt, wo man in einer kleineren Studie Behandlungserfolge nachweisen konnte. Zurzeit laufen mehrere Studien. Angesichts der Tatsache, dass es sich bei der Schuppenflechte um eine Autoimmun-Erkrankung s.

Lange galt, dass MTX besonders gut bei Psoriasisarthritis wirksam ist, allerdings konnte eine im Jahr publizierte randomisierte placebokontrollierte Studie keinen solchen Effekt zeigen. Bei den Biologicals unterscheidet man zwei Typen: Sie werden aber auch in anderen Indikationen eingesetzt z. PsoriasisarthritisRheuma und Morbus Crohn.

Der Phosphodiesterase-Hemmer Apremilast ist seit Januar zur Behandlung der mittelschweren bis schweren chronischen Psoriasis zugelassen. Die Substanz wurde Behandlung von Psoriasis nona zur Behandlung von Psoriasis-Arthritis bei Erwachsenen zugelassen. Die hier verwendeten Tabletten oder Spritzen wirken kurzfristig lindernd. Die innerliche Therapie der Psoriasis mit Kortikoiden wird heute nicht mehr empfohlen. Die immunsuppressive Substanz Ciclosporin ist zur Behandlung von schwersten therapieresistenten Formen einer Psoriasis zugelassen.

Dies wird Behandlung von Psoriasis nona durch Studienergebnisse untermauert, die eine deutliche Reduktion der Nagel-Psoriasis und positive Effekte auf Hyperkeratose und Onycholyse zeigen konnten. Klassifikation nach ICD L40 Psoriasis L Ansichten Lesen Bearbeiten Quelltext bearbeiten Versionsgeschichte. In anderen Projekten Commons. Diese Seite wurde zuletzt am Juni um ICD online WHO-Version Dieser Artikel oder nachfolgende Abschnitt ist nicht hinreichend mit Belegen beispielsweise Einzelnachweisen ausgestattet.

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Schuppenflechte Heilung mit Xemodan

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