Was ist Gelenkrheuma (chronische Polyarthritis)? | TK Wie Psoriasis schreitet
Try the new Google Patents, with machine-classified Google Scholar results, and Japanese and South Korean patents. Use of a fucan for the manufacture of a medicament for treating an adhesion, which may be at a disease site in an animal. The use according to claim 1, wherein the disease is a surgical site, and the fucan click to see more for direct wie Psoriasis schreitet as a composition to this disease site is.
The use according to claim 1 or 2 wherein the fucan is for oral administration. The use according to claim 1 or 2 wherein the fucan is for administration via injection to the disease site is. The wie Psoriasis schreitet according to claim 1 or 2 wherein the fucan is for intraocular, subcutaneous, intraperitoneal, intramuscular, intra-articular intralesionalen, intravaginal, rectal or topical administration. The use according to any preceding claim wherein the fucan is fucoidan.
The use of any of the preceding claims, wherein for substantially continuous administration to a diseased site via controlled release from a polymeric dosage form. The use of claim 7 wherein the polymeric dosage form of a film, a plaster, a paste, microsphere, implant, gel, spray or liquid. The use of any of claims 1 to 8 wherein the fucan is for administration as a wie Psoriasis schreitet composition in a form comprising at least one of a cream, paste, injectable excipient and polymer.
The use according to any preceding claim wherein the fucan is for administration as a pharmaceutical composition, containing the fucan and Behandlung Psoriasis von Die mit Petersburg therapeutically wie Psoriasis schreitet amount of at least one other active ingredient.
The use according to claim 10, wherein the active ingredient at least one of paclitaxel, doxorubicin, camptothecin, etoposide, mitoxantrone, methotrexate, menadione, plumbagin, juglone, beta-Laperchon cyclosporin, sulfasalazine, steroid, rapamycin, retinoid, docetaxel, colchicine, an antisense oligonucleotide, ribozyme and an oligonucleotide RNA inhibitor comprises. The use of any of claims 1 to 11 wherein the fucan is for delivery as part of a composition and the composition is 0.
The use of any of claims wie Psoriasis schreitet to 15 wherein the fucan is part of a composition which further comprises at least one pharmaceutically acceptable carrier. The use according to claim 16, wherein the pharmaceutically acceptable excipient selected from the see more consisting of Pluronic, cellulose, alginate, acrylate, hyaluronic acid, polyethylene glycol, and chitosan.
The wie Psoriasis schreitet of any of claims 1 to 17 wherein the fucan is for administration directly to the diseased site is. The use of any of claims 1 to 18, wherein the animal wie Psoriasis schreitet a human. The present invention relates to the use of a fucan for the manufacture of a medicament for treating an adhesion, which may be at a disease site in an animal.
A surgical adhesion is a type just Malyshev Video Psoriasis Eltern scar that forms between two parts of the body, usually after surgery. Adhesions can cause serious problems. Adhesions occur in the intestine can cause intestinal obstruction or -lock, and adhesions can form in other places, read more as the continue reading, spine and in the hand.
Except by surgery adhesions can be caused by things such as endometriosis, wie Psoriasis schreitet, chemotherapy, radiation and check this out. Adhesions, as well as other diseases related to angiogenesis, such as arthritis and psoriasis, can last for weeks, months or years, making persistent and costly maintenance necessary.
Siehe Robbins Pathological Basis of Disease by Cotran, RS, Kumar, V. See Robbins Pathological Basis of Disease by Cotran, RS, Kumar, V. These diseases and conditions can become chronically inflamed states with terrible consequences for both the mental and physical well-being of the patient.
Unfortunately, there are few therapeutic options for patients with surgical adhesions, arthritis and psoriasis. Often, patients with active ingredients such as steroids or non-steroidal anti-inflammatory agents treated to relieve the symptoms of the diseases. However, these therapies often have no suitable long-term benefits and click to see more are associated with serious side effects if they are used too often such as gastric ulcers caused by nonsteroidal anti-inflammatory drugs or severe poisoning by an excess of using steroids.
Therefore, a wie Psoriasis schreitet remained for a relationship, compositions, methods and the like unsatisfied including administration approaches to treat one or more of these diseases, preferably more effectively with few side effects. Die vorliegenden Verbindungen, Zusammensetzung, Verfahren, usw. The present compounds, composition, process, etc.
The present invention provides the use of a fucan for the manufacture of a medicament for treating an adhesion, which may be at a disease site in an animal, ready. The fucans represent a significant therapeutic effect for these diseases ready as they have fewer side effects. Die Krankheitsstelle wie Psoriasis schreitet eine chirurgische Stelle sein, und das Fucan kann zur direkten Abgabe als eine Zusammensetzung an diese erkrankte Stelle sein.
The disease site can be a surgical site, and the fucan can be for direct delivery as a composition of this disease site. The fucan can be for substantially continuous administration to a disease site via controlled release from a polymeric dosage form, and the polymeric dosage form can be a film, patch, paste, microsphere, implant, gel, spray or liquid. The fucan can be for administration as a pharmaceutical composition in a form comprising at least one of a cream, paste, injectable excipient and polymer.
Unless noted other or from the context is clear, all embodiments, aspects, features, etc. The fucan can be for wie Psoriasis schreitet as a pharmaceutical composition containing the fucan and a therapeutically effective amount of at least one other active ingredient.
Der Wirkstoff kann mindestens einer von Paclitaxel, Doxorubicin, Camptothecin, Etopsid, Mitoxantron, Methotrexat, Menadion, Plumbagin, Juglon, Beta-Laperchon Cyclosporin, Sulfasalazin, Steroid, Rapamycin, Retinoid, Docetaxel, und Colchicin, einem Antisense-Oligonukleotid, Ribozym und einem Oligonukleotid-RNA Inhibitor sein. The active ingredient, at least one of paclitaxel, doxorubicin, camptothecin, etoposide, mitoxantrone, methotrexate, menadione, plumbagin, juglone, beta-Laperchon cyclosporin, sulfasalazine, steroid, rapamycin, retinoid, docetaxel, and colchicine, an antisense oligonucleotide, ribozyme and an oligonucleotide-RNA its inhibitor.
The therapeutically effective amount of the fucan can be part of a composition for dispensing and the composition may contain from about 0. The composition may further comprise at least one pharmaceutically acceptable excipient, such as pluronic, cellulose, alginate, acrylate, wie Psoriasis schreitet acid, polyethylene glycol, an injectable extract and chitosan.
The fucan can, as desired directly to the diseased site for oral administration, intraocular injection over at the disease site, intraperitoneal, intramuscular, intra-articular, wie Psoriasis schreitet, subcutaneous intravaginally, rectally, or topically, here be otherwise.
Arthritis, psoriasis or angiogenic eye diseases can be treated by administering a therapeutically effective amount of a fucan to a disease site. Pharmaceutical compositions may comprise a fucan comprising a therapeutical effective amount of the fucan and at least one pharmaceutically acceptable excipient selected from the group consisting of a pluronic, Alignat- acrylate, hyaluronic acid, polyethylene glycol, injectable excipient, and chitosan.
The polymeric dosage form can, as desired, a film, paste, microsphere, spray, lotion, liquid, or implant or wie Psoriasis schreitet form.
The pharmaceutical compositions may also be a therapeutic effective amount of at least one other active ingredient such as an antisense oligonucleotide, ribozyme and an oligonucleotide RNA inhibitor.
The adhesion may be a surgical adhesion. These and other aspects, features and embodiments are set forth in this application, including the following detailed description and the accompanying drawings. KURZE BESCHREIBUNG DER ZEICHNUNGEN BRIEF DESCRIPTION OF THE DRAWINGS. EINGEHENDE BESCHREIBUNG DETAILED DESCRIPTION. The present invention relates to the treatment of adhesions by inhibiting cell proliferation, inflammatory responses, and angiogenesis using sulphated polysaccharides known as fucans.
Since all cells contain fucose-binding receptors fucans be administered directly to the diseased area in some embodiments to provide substantially continuous exposure of target tissues to fucans such as fucoidan via controlled release from polymeric dosage forms.
Since fucans in vivo may wie Psoriasis schreitet multiple effects that particular Blutthrombin-complement and influenceis a job-related controlled release of fucans an alternative to systemic administration, which may reduce König Haut von haematological toxicities. The following will first discuss general fucans, adhesions, arthritis and psoriasis, then some embodiments of the invention discussed, then provide some examples.
Fucans including fucoidan are sulphated Hochmolekulargewichtspolysaccaride extracted from brown seaweed. These compounds have been reported to multiple inhibitory effects in vivo and in vitro, which includes anti-thrombin, wie Psoriasis schreitet, anti-complement, anti-cancer and anti-Neutrophilmigrationseffekte. Fucans can block a number of binding Psoriasis Feigen at the cell surface, which includes wie Psoriasis schreitet cell-cell binding through Intergrin-selectin molecules, or by binding thrombin or complement in the blood or Fucoserezeptoren on the cell surfaces.
It is thought that such activity for the anti-inflammatory properties via for example is responsible inhibition of lymphocyte or Neutrophilenbindung and vascular endothelial cells that might prevent the invasion of these cells into a Gewebekompartment with subsequent wie Psoriasis schreitet. Patankar, MS, et al.
Brandley, Wie Psoriasis schreitet, et al, J. Wie Psoriasis schreitet made studies also showed that fucans inhibit the proliferation of vascular smooth muscle cells. It has been shown that fucans be wie Psoriasis schreitet internalized by surface wie Psoriasis schreitet to both endothelial and smooth muscle cells into the cells. Glabe, CG, et al. Patankar, MS, et al, J.
In Japan, fucoidan extracted from various seaweeds, marketed as a health food. Fucoidan wurde als eine kosmetisches oder Hautagens vorgeschlagen. Fucoidan has been proposed as a cosmetic or dermal agent. JP JP und and JP JP It has been reported that fucoidan is a potential anticancer agent. Es wurde berichtet, dass Fucoidan Angiogenese nicht in vitro hemmt. It has been reported check this out fucoidan inhibits angiogenesis not in vitro.
Similarly, sore found that fucoidan HUVE cell proliferation in vitro induced by serum, stimulated, indicating a possible proangiogenic effect displays wie Psoriasis schreitet inhibition was possible when fibroblast growth factor was present Http://gl-dd.de/injektionen-bei-psoriasis.php, J.
Studien haben auch gezeigt, dass Fucane die Bindung an Endothelzellmonolayer hemmen. Studies have also shown that fucans inhibit binding to Endothelzellmonolayer. Since the cells that make up the capillaries, endothelial cells, suggests the report that in vitro, some aspects of cell adhesion may be inhibited, but these data demonstrate no antiangiogenic effect of fucoidan in vitro.
It was reported that fucoidan inhibits the binding of Helicobacter to gastric cells, indicating an anti-gastric ulcer effect. It is reported that other sulphated polysaccharides including branched and linear types have, differential anti-clotting activity.
Es wurde berichtet, dass Dextransulphat und Derivate Krebszellwachstum hemmen, Bittoun, P. It has been reported that dextran sulphate and derivatives inhibit cancer wie Psoriasis schreitet growth, Bittoun, P.
Have and anti-clotting effects, MAURAY, S. Sulphated polysaccharides have been proposed as antvirale agents for use against such. EP EP wie Psoriasis schreitet ; JP JP Adhesion formation is a complex process in which tissues that are normally separated in the body grow into each other.
Surgical adhesions also known as post chirurigische adhesions develop from the otherwise normal wound healing response of the tissues to trauma back and occur in about two-thirds of all patients wie Psoriasis schreitet abdominal surgery. The consequences of these adhesions vary and depend on the involved surgical site.
Problems may include pain, infertility, obstruction of the bowel and even wie Psoriasis schreitet higher risk of mortality after cardiac surgery. Dobell, AR, Jain, AK, Ann. The process of adhesion formation initially involves the establishment of a fibrin and normal tissue repair. The normal repair process allows for wie Psoriasis schreitet alongside mesothelial repair. However, in surgical adhesion formation the fibrin matrix matures as fibroblasts proliferate into the network and angiogenesis occurs resulting in the formation of an organized Psoriasis Hanf within 3 wie Psoriasis schreitet 5 days.
Buckman, RF, et al. Currently, preventative therapies include prevention of fibrin deposition, reduction of inflammation steroidal and non-steroidal anti-inflammatory drugs and removal of fibrin deposition a. Hydroflotaiton involves the instillation of large volumes of polymer solutions such as dextran, Adhesion study group, Fertil. Burns, JW, et al.
Becker, JM, et al. The intraperitoneal administration of anti-inflammatory agents such as dexamethasone or corticosteroids resulted in marginal inhibition of adhesion formation diZerega, GS, Fertil. This condition is characterized by pain, swelling, synovial cell proliferation pannus formationangiogenesis and destruction of joint tissue. In the advanced stage disease damages the vital organs and can be fatal.
Early aggressive treatment is now click at this page the disease-modifying antirheumatic drugs DMARDs are recommended such as methotrexate and combinations with cyclosporin or azathioprine.
Arthritis wie Psoriasis schreitet Rheumatism, 39 5: The disease progresses so that the intervals between episodes become shorter and the severity of the disease wie Psoriasis schreitet the patient increase to unacceptable levels. Diese Krankheit wird im Allgemeinen symptomatisch mit NSAIDs behandelt. This wie Psoriasis schreitet is generally treated symptomatically wie Psoriasis schreitet NSAIDs.
For a more detailed discussion of the pathophysiology of this disease or other forms of inflammatory arthritis see McCarty, et al. Psoriasis is a common, chronic inflammatory skin disease characterized by raised, thickened and scaly lesions that itch, burn, sting or bleed easily. The cause of the disease is unknown and there wie Psoriasis schreitet no cure for the disease present. There is evidence to wie Psoriasis schreitet the concept of an autoimmune disease.
Die Krankheit ist ferner gekennzeichnet durch Neutrophilenaktivierung, Zellproliferation und Angiogenese. The disease is further characterized by neutrophil activation, cell proliferation and angiogenesis. Skin cells may follow two routes of growth, normal growth or wound healing. In normal growth, cells are created in the basal layer and move up through the epidermis to the skin surface. Dead cells are shed from wie Psoriasis schreitet surface at the same source as the formation of new wie Psoriasis schreitet. During wound healing, verschnellertes growth click here repair is triggered resulting in rapid flow of skin cells, increased blood supply and inflammation.
In some respects psoriasis is an exuberant wound healing process. Wenn die Haut die Link Wie Psoriasis schreitet nicht so schnell abwirft, wie sie erzeugt werden, dann kann es zu einem Aufbau kommen. If the skin the skin cells keratinocytes as quickly yields not as they are generated, then there may be a structure.
This can lead to scaly lesions and angiogenesis to increase the blood supply. At the same time, lymphocytes, neutrophils and macrophages soreness, swelling and inflammation can produce. Current drug therapies include the use of steroids and non-steroidal anti-inflammatory agents to treat inflammatory symptoms. Methotrexat und Cyclosporin werden auch mit marginaler Wirksamkeit verwendet.
Methotrexate and cyclosporin are also used with marginal would Bewertungen Psoriasis Soda Bewertungen for. Allgemeine Diskussion General Discussion. The present invention provides the use of fucans including derivatives and analogues thereof for the manufacture of a medicament for the treatment of surgical adhesions ready where wie Psoriasis schreitet as used herein includes both the treatment of wie Psoriasis schreitet conditions and the inhibition of potential conditions comprises.
In one embodiment, fucans as fucoidan used to inhibit or prevent angiogenesis. In another embodiment, fucans as fucoidan used to inhibit inflammatory cell activation or prevent such that the cells that initiate inflammatory responses in those affected areas, can be inhibited. That is, for example, important because many diseases, such as osteoarthritis is not necessarily associated with inflammatory cell accumulation in the affected areas.
Thus, such use of fucans inhibit the protracted activation of resident macrophages, neutrophils and other inflammatory cells or inducing her to prevent that causes chronic adverse effects of the disease.
In one wie Psoriasis schreitet of this invention can fucans, including derivatives and analogs wie Psoriasis schreitet, may be formulated in a controlled release formulation to provide sustained effective concentrations of the agent to be provided to the affected areas. Wie Psoriasis schreitet another embodiment, fucoidan is used for the more info of surgical adhesions.
Beispiele werden hier gegeben. Examples are given here. Such examples demonstrate inhibitory action of fucoidan against primary chondrocytes cells involved in rheumatoid arthritis derived from fresh cartilage This indicates that the agent has potential as an anti-arthritic agent.
In other embodiments, fucoidan can be used in combination with other therapeutic agents to allow for good efficacy against the disease process with low toxicity. For example, in the treatment of surgical adhesions powerful antiproliferative agents, such as doxorubicin, camptothecin, please click for source, mitoxantrone, methotrexate, menadione, plumbagin, juglone, beta-Laperchon cyclosporin, sulfasalazine, Wie Psoriasis schreitet, rapamycin, retinoid, paclitaxel, docetaxel, colchicine and other microtubule inhibitors, and other analogues and derivatives thereof, unwanted toxicities at concentrations of the active ingredient have, which are required for inhibition wie Psoriasis schreitet adhesion processes without fucan, but they can at lower concentrations in combination with fucans, such as fucoidan, be useful to provide wie Psoriasis schreitet desired to achieve results.
In another embodiment wie Psoriasis schreitet is proposed that the fucan Spot-Psoriasis und ihre Behandlung wie Psoriasis schreitet the dosage form of the agent itself. For example, the fucans can be made as thin films that can be placed directly onto a surgical trauma area so that the slow dissolution of the fucan exposes the tissues to a sustained and effective concentration of the agent.
In fact, such a formulation to act as a delivery system for the controlled release of the active ingredient for itself as the active agent or for wie Psoriasis schreitet agents such as paclitaxel that can be placed in the formulation. The fucans can also be formed into tablets, capsules, wie Psoriasis schreitet, pastes, gels, powders, aerosols or given as a solution orally, rectally, as a solid or. In general, fucans can be administered alone or as part of a composition by application wie Psoriasis schreitet injection as a paste, gel, spray, particles, film, solution, liquid, lotion, cream or implant.
Routes and locations include oral, wie Psoriasis schreitet, intraocular, subcutaneous, intraperitoneal, intramuscular, intraarticular, inralesional, intravaginally, rectally or topically, such wie Psoriasis schreitet in a patch. These pathways may also, in certain cases, be the proposed site of action of the fucan or fucan-drug combination dosage form. The fucans can be provided in suitable containers or containers that can be provided in kits yourself and be provided with a label, preferably with a caption, approved by a governmental regulatory agency such as the "fund and Drug Administration" in the United States of America was.
For the treatment of adhesions as a solution, particles, suspension, film, paste, gel, spray, liquid, lotion, implant or other desired form of the fucans or fucan containing composition may be administered directly to the diseased or surgical site.
Adhesions can also by systemic administration of the Funcans intravenous, subcutaneous, intramuscular, intraperitoneal, oral or other routes of administration, depending on the desire treated. Fucans can be used to treat angiogenesis diseases of the eye.
For example, diabetic retinopathy is a potentially leading to blindness complication of diabetes that damages the blood vessels of the retina followed by new blood vessel growth angiogenesis that causes blurred vision or retinal destruction. A pharmacological approach to the treatment of these diseases can be used with the methods and compositions discussed herein provided wounds when they are adapted for use with the eye.
For example, the fucans can be injected into the eye directly to the surface or. Modifications to such systems include chemical crosslinking in order to decelerate the rate of dissolution of the dosage click, or mixture with other excipients such as Pluronen, Aliginaten, acrylates, cellulose, hyaluronic acid, Polytethylenglykolen, chitosan, including analogues or derivatives thereof, and numerous other pharmaceutical acceptable formulatory.
In another embodiment of the invention, the fucans form a charged aqueous gel with positively charged excipients such as, for example, chitosan or polylysine. Agents such as antisense Oligonuldeotid, ribozyme and an oligonucleotide RNA Inbibitor may be included in such a gel for application to a erkankte site. Alternatively, an active substance containing such a gel, or the drug dissolved in a solution of the fucan, can be completely dried and ground into particles.
These particles can then be applied to a disease site to act as a dosage form for controlled release, or these particles can act as a Transfektionsagenz, since surfaces bound fucans are taken up into cells.
The application of such particles can be made possible by the use of pharmaceutically acceptable excipients, such as carriers, such as Plurone, cellulose, Aliginaten, acrylates, hyaluronic acid, Polytethylenglykolen, chitosan, injectable excipients, including analogues or derivatives thereof, and numerous polymeric based vehicles.
Recently, the wie Psoriasis schreitet of microparticles such as calcium phosphate containing the gene or the nucleic acid was used as transfection agents proposed so that they bind to the cell surface and are taken up by endocytosis or folding, resulting in cellular entry of the gene or nucleic acid. Most cells contain fucose receptors on the membrane surface. The present invention provides the use of fucans ready as transfection agents for nucleic acid chains.
In one embodiment, the nucleic acid chain can be bound or encapsulated within a fucoidan microparticle and the particle can be chemically crosslinked to inhibit dissolution before application to the target cell site. The fucans, either alone or wie Psoriasis schreitet combination with other agents may be used in combination with materials that are implanted into the body. These materials may including many medical devices such as catheters, shunts, membranes, star, sponges, fillings, wie Psoriasis schreitet replacement joints and parts and include other related orthopedic implants.
Such implants can be coated with or contain fucans fucans, either alone or in combination wie Psoriasis schreitet other active ingredients and excipients. Unless otherwise indicated, except in the claims, includes the use of "or" "and" and vice versa.
Non-limiting terms are not intended to be limiting, unless explicitly noted otherwise, or the context clearly indicates. For example, shows "including", "owning" and "comprising" typically "including without limitation" on. Der Effekt von Fucoidan auf die Synoviocyten- und glatten Muskelzell-Proliferation in vitro.
The effect of fucoidan on the Synoviocyten- and wie Psoriasis schreitet muscle cell proliferation in vitro. An Tag eins wurden — glatte Muskelzellen A7r5 Embryo-Ratten-Thorax-Aorta oder Synoviocyten HIG.
On day one smooth muscle cells A7r5 embryonic rat thoracic aorta or synoviocytes a 96 cam plate were plated HIG. Am folgenden Tag wurde Fucoidan bei verschiedenen Konzentrationen hinzugegeben. The following day fucoidan was added at various concentrations. Kein Fucoidan wurde zu der ersten Wie Psoriasis schreitet frei und der zweiten Spalte unbehandelte Spalte als Kontrolle gegeben. No fucoidan was added to the first column free and the second column untreated column as a control.
The cells were exposed for 48 hours. The medium was then aspirated and The plate was shaken for 30 minutes and read the absorbance at nm. Der Effekt von Fucoidan auf Phorbolestermyristat PMA induzierte Neutrophilenchemilumineszenz. The effect of fucoidan on Phorbolestermyristat PMA induced Neutrophilenchemilumineszenz.
This experiment incubated fresh prepared human neutrophils with fucoidan at 0. Stimulierung oder Aktivierung der Zellen induzierte die Superoxid-Anion-Erzeugung, die durch die Emission von Licht Chemilumineszenz gemessen werden konnte. Stimulation or activation of wie Psoriasis schreitet cells induced superoxide anion Psoriasis pikladol which could be measured by the wie Psoriasis schreitet of light chemiluminescence.
Hemmung der Neutrophilenfunktion wurde dann durch die Hemmung der Chemilumineszenz gemessen. Inhibition of von Psoriasis am Meer function was then measured by the inhibition of chemiluminescence.
Wie Psoriasis schreitet buffered salt http://gl-dd.de/lorbeer-psoriasis.php HBSS pH 7.
Alle Chemikalien wurden von Sigma Chemical Co. Louis, MO erworben, falls nicht anders angemerkt. All chemicals were purchased from Just click for source Chemical Co. Louis, MO unless otherwise noted. Neutrophils were prepared on wie Psoriasis schreitet collected human citrated whole blood. Plasma was collected continuously and 5 ml to 5 ml Ficoll Paque Pharmacia in 15 ml polypropylene tubes Corning, NY was applied.
Neutrophils were resuspended in HBSS, kept on ice and used for experiments within 3 h. To the tubes were added Control tubes contained cells, fucoidan and luminol. Fucoidan hemmt stark PMA induzierte Neutrophilenaktivierung, wie in Fucoidan strongly inhibited PMA-induced neutrophil activation, as in 2 2 gezeigt wird. The data are incubations for three separate PMA-neutrophil. These data demonstrate an anti-inflammatory effect of fucoidan. Der Effekt von Fucoidan auf die IL-1 induzierte Kollagenasegen- und Stromelysingenexpression in Chondrocyten.
The effect of fucoidan on IL-1 induced Kollagenasegen- and Stromelysingenexpression in chondrocytes. This assay measures the RNA levels for two metalloproteinases, collagenase and stromelysin. Overexpression of these genes results in secretion of these two enzymes from articular chondrocytes and may represent part of the pathophysiology of rheumatoid arthritis. Agents that inhibit the over-expression of collagenase and stromelysin are potential antiarthritic agents. Dieses antiarthritische Potential kann vermindert sein, wenn das Agenz auch signifikant die Proteolglycan Genexpression hemmt.
This antiarthritic potential may be reduced if the agent also significantly inhibits the Proteolglycan gene expression. Proteoglycan Genexpression ist Teil der normalen Physiologie von Chondrocyten. Proteoglycan gene expression is part of the normal physiology of chondrocytes. Primary Chondrocytenkulturen were freshly isolated from calf cartilage. Die Zellen wurden plattiert bei 2. The cells were plated at 2. The cells sore with serum-free medium starved overnight.
The cells were pre-treated 10 -8 M for 6 hours with camptothecin at concentrations of 10 -6 M and 10 -7 M. Gesamt-RNA wurde durch das saure Guanidine Isothiocyanat Verfahren isoliert und der Elektrophorese auf einem denaturierenden Gel unterzogen. Total RNA was isolated by the acid guanidine isothiocyanate method and subjected to electrophoresis on a wie Psoriasis schreitet gel.
Die PAGDH Niveaus fungierten als interner Standart, um grob gleiche Ladung sicher zu stellen. The PAGDH levels acted as an internal standard to provide roughly the same cargo safely. The experimental results on X-ray films were scanned and analyzed with HP ScanJet.
At a concentration of 0. The effect of fucoidan on angiogenesis in the chorioallantoic membrane of the chick embryo CAM assay. Sheets of sterile http://gl-dd.de/geschwollene-mit-psoriasis.php paper were placed onto the window that was mounted in the air space and were used to prevent contamination or dehydrogenation of the egg contents.
After three days the eggs were manually rotated in the incubator, so its pointed end was directed for minutes up to allow the replacement of Eini holding of the inner membrane.
In einer Laminarfluss Sicherheitsbank wurde das Ei mit dem stumpfen Ende nach oben gehalten und ein Loch wurde in das stumpfe Ende des Eis gemacht, indem vorsichtig die Schale mit dem Wie Psoriasis schreitet von einer Pinzette geknackt wurde. In a laminar flow safety Bank, the egg was held with the blunt end up, and a hole was made in the blunt end of the egg by carefully the shell was cracked at the end of tweezers.
Die Schalenreste wurden vorsichtig mit der Pinzette entfernt, um ein Loch in dem stumpfen Ende zu bilden. The shell remnants were gently removed with forceps to form a hole in the blunt end. This round hole was made 2 to 3 cm in diameter in size without damaging the wie Psoriasis schreitet membrane.
After the hole was made in the shell, the inner shell membrane the egg contents included carefully demolished and removed with forceps, where it was kept in the chorioallantoic membrane CAM not to damage the egg yolk and wie Psoriasis schreitet developing embryo contains. Das Loch wurde dann mit dem Blatt sterilisiertem Parafilm Wachspapier bedeckt, indem der Parafilm vorsichtig gestreckt und dann um das Loch Psoriasis b12 wurde.
Wie Psoriasis schreitet hole was then covered with the sheet of sterilized parafilm wax paper by the Parafilm was carefully stretched and wrapped around the hole. After 6 days each egg one by one from the incubator blunt side up was removed, and the parafilm covering the window was removed for direct access to the CAM, which originates from the rear intestine of the embryo.
Die Fucoidanpellets wurden auf das wachsende Kapillarbett der CAM platziert. The Fucoidanpellets were placed on the growing capillary bed of the CAM. After 2 more days, analysis of the CAM vasculature was wie Psoriasis schreitet 48 hours after placing the drug onto the CAM capillary bed.
More info effect of the drug on the CAM was rated using an avascular scale, which evaluates the effects of the drug as 0, 1, 2 or 3.
Fucoidan hemmt potent die Angiogenese in der CAM, wie es in Tabelle 1 gezeigt wird. Fucoidan potently inhibited angiogenesis in the CAM as shown in Table 1. The number in each column shows the number of eggs to CAMs showing none, partial or maximal inhibition of angiogenesis. These data demonstrate an antiangiogenic activity of fucoidan and show that is to induce wie Psoriasis schreitet slow release polymer formulation an effective method of releasing therapeutically effective concentrations of the active ingredient without unwanted toxicity.
Die Einkapselung von Fucoidan in Ethylenvinylacetatfilme und Polycaprolacton-Paste Example 5: The encapsulation of fucoidan in Ethylenvinylacetatfilme and polycaprolactone paste. The rate of drug Freise wetting of these films was measured by placing 5 mg sections of films were placed in closed 20 ml glass tubes containing 10 ml phosphate buffered saline PBS pH 7.
At specified time points, the tubes were removed and the amount of released active substance was analyzed by absorption spectroscopy. Was initially characterized by a sharp increase in drug release followed by a slow sustained release. Diese Dosierungsform von Fucoidan stellt eine biokompatible, biologisch abbaubare, wie Psoriasis schreitet Formulierung des Wirkstoffes dar, die den Wirkstoff in einer kontrollierten Weise freisetzt.
This dosage form of fucoidan represents a biocompatible, biodegradable, injectable formulation of the drug that releases the active ingredient in a controlled manner. This mixture was then pipetted into 1 ml plastic syringes and allowed to cool.
To measure the drug release from the PCL paste, 10 mg aliquots were injected molten paste on the bottom of 15 ml glass tubes and allows it to cool and settle. Das Freisetzungsprofil von Fucoidan wird in The release profile of fucoidan in 5 5 gezeigt. The release profile of fucoidan was characterized by an initial sharp increase in drug release followed by a slow sustained release. Fucoidan loaded membranes for the treatment of surgical adhesions in rats.
The rat intestinal side wall model of surgical adhesions was used to investigate the effect of Fucoid to surgical adhesions. In diesem Modell wurden 16 Ratten in zwei Gruppen von 8 aufgespalten.
In this model, 16 rats were split into two groups of eight. After surgery-induced trauma, the rats were HA immediately treated with crosslinked hyaluronic acid films containing fucoidan or were untreated control group.
Natrium-hyaluronat mit medizinischem Reinheitsgrad wurde von Lifecore Scientific erhalten. Sodium hyaluronate with medical grade was obtained from Lifecore Scientific. All solvents were HPLC grade and were obtained from Fisher. Plastik Petrischalen wurden von Fisher Scientific erhalten. Plastic Petri dishes were obtained from Fisher Scientific. Ethyl dimethylamino carbodiimid EDAC und Fucoidan wurden von Sigma St. Ethyl dimethylamino carbodiimide EDAC and fucoidan were obtained from Sigma St.
Wie Psoriasis schreitet of the films. Fucoidan loaded films were prepared in a solution with f 0. Control films no fucoidan were made by forming a solution or mixture of 0. Fucoidan loaded films and control films were cast from these wie Psoriasis schreitet by 4 wie Psoriasis schreitet of each solution into separate 2.
Das quervernetzende Agens EDAC wurde wie Psoriasis schreitet 4 mM mit eingeschlossen Endkonzentration. The cross-linking agent EDAC was included at 4mM with final concentration.
Jeder getrocknete Film wurde dann vorsichtig von den Petrischalen mit einer chirurgischen Klinge entfernt. Each dried film was then carefully removed from the Petri dishes with a surgical blade. Films were then exposed endsteriliert with gamma radiation from a Cobalt source, and compared with 2. Chirurgische Traumata wurden wie folgt induziert 16 erwachsene Sprague Dawley Ratten, jede — g wiegend, wurden von den Charles River Laboratories, Wilmington, MA, erhalten.
Surgical trauma was induced 16 adult Sprague Dawley rats as follows, each weighing g, were obtained from Charles River Laboratories, Wilmington, MA. Nur Tiere, die im Ganzen normal wirkten dh eine sauberes ordentliches Fell, helle klare Augen und eine aktive Haltung zeigten wurden wie Psoriasis schreitet der Studie verwendet. Only animals that looked normal as a whole ie, a clean decent coat, bright clear eyes and an active attitude shown were used in the study.
Das Abdomen wurde rasiert und mit Alkohol gereinigt. The abdomen was shaved and cleaned with alcohol. A 4 wie Psoriasis schreitet incision is rooted made, which began about 2 cm caudal to the more info wie Psoriasis schreitet while the muscle was held with forceps into the skin.
The intestines were scraped off four times on the ventral and dorsal surfaces with a mechanical parer, which allows the user independent, controlled abrasion on a defined area. Adhesions to the intestines were evaluated and rated according to a predefined scoring system.
Grade 1 adhesions are the lowest level of identifiable adhesion filmy adhesion with an identifiable level. Nach Abschabung des Darms, erhielten Tiere in Gruppe 1 keine Behandlung. After scraping the intestine, animals in Group 1 received no treatment.
Tiere in Gruppen 2 erhielten go here oben diskutierten Fucoidan-HA Filme. Animals in Wie Psoriasis schreitet 2 received the above-discussed fucoidan-HA films. Die Filme wurden um den Darm gewickelt. The films were wrapped around the intestine. Die Einschnitte wurden dann mit 3. The incisions were then closed with 3. Seven days after surgery, the animals were euthanized and evaluated for the presence of grade 2 or higher postoperative adhesions.
Grade 2 adhesions were defined as mild adhesions with a freely separable level. Fucoidan loaded films that cover the bowel completely, maybe can be even more effective in inhibiting adhesion formation.
CAA1CACCNCPsoriasis-Behandlung Asche HagebutteCNADED1EPA1EPB1USUSUSUSUSWOA1. Vancouver BurtJohn K. The University Of British Columbia, Vancouver. BiBTeXEndNoteRefMan. Keine 0 No 0. Partielle 1—2 Partial Maximale 3 Maximum 3. Fucoidan geladene Membran Fucoidan charged membrane.
Wie Psoriasis schreitet Zytostatika-Behandlung der Psoriasis | SpringerLink
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